| Date | Home | Away | Result |
|---|---|---|---|
| 9/12/25 1:30 PM | US Avellino | AC Monza | 2-1 |
| 9/13/25 8:00 AM | Juve Stabia | AC Reggiana 1919 | 0-0 |
| 9/13/25 8:00 AM | Modena FC | SSC Bari | 3-0 |
| 9/13/25 8:00 AM | Padova Calcio | Frosinone Calcio | 0-1 |
| 9/13/25 8:00 AM | Pescara Calcio | FC Venice | 2-2 |
| 9/13/25 10:15 AM | US Catanzaro 1929 | Carrarese Calcio 1908 | 1-1 |
| 9/13/25 12:30 PM | Sampdoria Genua | FC Cesena | 1-2 |
| 9/14/25 8:00 AM | Virtus Entella | Mantova 1911 | 1-0 |
| 9/14/25 10:15 AM | FC Südtirol | Palermo FC | 0-2 |
| 9/14/25 12:30 PM | FC Empoli | Spezia Calcio | 1-1 |